Which syndrome affecting young patients does not include severe periodontitis as part of the syndrome?

• A. Down Syndrome
• B. Peutz-Jeghers Syndrome
• C. Chediak-Higashi Syndrome
• D. Papillon-Lefevre Syndrome

Answer: (B)

Understanding which syndromes come with periodontal problems helps distinguish those with dental-inflammation features from those without. Papillon-Lefèvre syndrome is known for aggressive, early-onset periodontitis leading to rapid loss of both baby and permanent teeth, due to a genetic defect affecting the immune-inflammatory response. Chediak-Higashi syndrome also involves immune system dysfunction that can manifest as gingivitis and early periodontal destruction. Down syndrome frequently shows higher risk and severity of periodontal disease because of immune and tissue susceptibility. Peutz-Jeghers syndrome, however, is characterized by mucocutaneous pigmented spots and hamartomatous polyps of the gastrointestinal tract; it does not have severe periodontitis as a characteristic part of the syndrome. Hence, the syndrome that does not include severe periodontitis is Peutz-Jeghers.